A mediator lost in the war on cancer.
basic_science · Level V
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- Record sourced from PubMed, PMID 23178113.
- Also identified by DOI 10.1016/j.cell.2012.11.003.
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Abstract
An unexpected role for a Mediator subunit, MED12, in resistance to multiple anticancer agents is revealed by Huang et al. Loss of MED12 confers drug resistance by activating transforming growth factor b (TGF-b) signaling. Inhibition of the TGF-b pathway resensitizes cells to therapeutic drugs, suggesting a new combinatorial cancer treatment.