Designing an enhancer landscape.
editorial · Level V
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- Record sourced from PubMed, PMID 23178114.
- Also identified by DOI 10.1016/j.cell.2012.11.007 and PMC identifier 3732118.
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Abstract
In this issue and in a recent issue of Cell, Vahedi et al. and Samstein et al. provide new insights into the strategies used to establish an enhancer landscape during development of cell lineages. They report that enhancer landscapes characterizing T cell lineages are pre-established and strongly influenced by environmental stimuli.