Extracellular matrix heterogeneity regulates three-dimensional morphologies of breast adenocarcinoma cell invasion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184641.
- Also identified by DOI 10.1002/adhm.201200320 and PMC identifier 4074172.
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Abstract
Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.
Medical subject headings
- Adenocarcinoma
- Breast Neoplasms
- Extracellular Matrix
- Microfluidic Analytical Techniques