Anisotropic collagen fibrillogenesis within microfabricated scaffolds: implications for biomimetic tissue engineering.
basic_science · Level V
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- Record sourced from PubMed, PMID 23184695.
- Also identified by DOI 10.1002/adhm.201100017.
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Abstract
Anisotropic collagen fibrillogenesis is demonstrated within the pores of an accordion-like honeycomb poly(glycerol sebacate) tissue engineering scaffold. Confocal reflectance microscopy and image analysis demonstrate increased fibril distribution order, fibril density, and alignment in accordion-like honeycomb pores compared with collagen gelled unconstrained. Finite element modeling predicts how collagen gel and scaffold mechanics couple in matching native heart muscle stiffness and anisotropy.
Medical subject headings
- Biomimetic Materials
- Collagen
- Extracellular Matrix
- Tissue Engineering
- Tissue Scaffolds