Magnetic scaffolds enriched with bioactive nanoparticles for tissue engineering.

Skaat, Hadas; Ziv-Polat, Ofra; Shahar, Abraham; Last, David; Mardor, Yael; Margel, Shlomo · Adv Healthc Mater · 2012

basic_science · Level V

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Abstract

Novel magnetic fibrin hydrogel scaffolds for cell implantation and tissue engineering are reported. The magnetic scaffolds are produced by the interaction between thrombin-conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. These scaffolds, enriched with growth factor conjugated fluorescent maghemite nanoparticles, provide a supporting 3D environment for massive proliferation of various cell types, and can be successfully visualized by MRI.

Medical subject headings