Efficient cell reprogramming using bioengineered surfaces.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184721.
- Also identified by DOI 10.1002/adhm.201200017.
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Abstract
A novel method for cell reprogramming is been developed by immobilizing nucleic acid transfer vectors containing free amino groups, like lentiviral particles, onto pentafluorophenyl methacrylate (PFM)-modified surfaces obtained by PFM grafting affter Ar plasma treatment. This technique is able to reprogram murine somatic cells into pluripotent cells at high efficiencies. We call these modified surfaces cell reprogramming surfaces, or CRS.
Medical subject headings
- Biocompatible Materials
- DNA
- Pluripotent Stem Cells
- Transfection