Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184747.
- Also identified by DOI 10.1002/adhm.201100030.
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Abstract
A nanoreservoir for efficient intracellular anticancer drug delivery based on mesoporous silica nanoparticles end-capped with lactobionic acid-grafted bovine serum albumin is fabricated. It demonstrates great potential for both cell-specific endocytosis and intracellular pH-responsive controlled release of drugs. A possible endocytosis pathway/mechanism of the smart controlled drug release system is proposed.
Medical subject headings
- Delayed-Action Preparations
- Disaccharides
- Doxorubicin
- Nanocapsules
- Serum Albumin, Bovine
- Silicon Dioxide
- Subcellular Fractions