Lipophilic silver nanoparticles and their polymeric entrapment into targeted-PEG-based micelles for the treatment of glioblastoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184752.
- Also identified by DOI 10.1002/adhm.201100047.
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Abstract
A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.
Medical subject headings
- Drug Carriers
- Glioblastoma
- Metal Nanoparticles
- Nanocapsules
- Polyethylene Glycols
- Silver