Delivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184753.
- Also identified by DOI 10.1002/adhm.201200022 and PMC identifier 4119887.
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Abstract
Mesoporous silica nanoparticle-supported lipid bilayers, or "protocells", exhibit a high loading capacity, enhanced colloidal stability, and peptide-directed, cell-specific uptake, making them especially well-suited for targeted delivery of protein toxins to cancer. Protocells loaded with ricin toxin A-chain (RTA) and targeted to hepatocellular carcinoma cause complete cell death at 30 pM of RTA without affecting the viability of control hepatocytes.
Medical subject headings
- Carcinoma, Hepatocellular
- Lipid Bilayers
- Nanocapsules
- Ricin
- Silicon Dioxide