Assembly of discrete collagen-chitosan microenvironments into multiphase tissue constructs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184758.
- Also identified by DOI 10.1002/adhm.201200346 and PMC identifier 4001864.
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Abstract
Modular assembly of protein-polysaccharide microenvironments into 3D macroscale tissue constructs is reported. Rapid and simple centrifugation and vacuum molding methods are used to create cohesive multiphase constructs with prescribed geometries. Human fibroblasts are shown to survive in the microenvironments and in the macroscale constructs. Control of the spatial organization in engineered tissues is a key to recreating the complex tissue architectures needed for regenerative therapies.
Medical subject headings
- Biocompatible Materials
- Biomimetic Materials
- Chitosan
- Collagen Type I
- Fibroblasts
- Tissue Engineering