Microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184773.
- Also identified by DOI 10.1002/adhm.201200046 and PMC identifier 3508764.
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Abstract
A low-cost and rapid microfluidic cell sorter (μFCS) for circulating tumor cell (CTC) detection, culture and analyses is developed. Based on size separation and molecular characterization, μFCS efficiently enriches CTCs from unprocessed whole blood, allows on-chip culture and molecular profiling, and provides cell retrieval for subsequent analyses. The potential clinical application of the technology is demonstrated by capturing and genetically analyzing CTCs in tumor-bearing mice.
Medical subject headings
- Biological Assay
- Cell Separation
- Flow Cytometry
- Microfluidic Analytical Techniques
- Neoplastic Cells, Circulating