Regulating specific growth factor signaling using immobilized branched ligands.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184776.
- Also identified by DOI 10.1002/adhm.201200077 and PMC identifier 3925890.
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Abstract
VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.
Medical subject headings
- Drug Carriers
- Endothelial Cells
- Intercellular Signaling Peptides and Proteins
- Peptides
- Signal Transduction