Hybrid BaYbF(5) nanoparticles: novel binary contrast agent for high-resolution in vivo X-ray computed tomography angiography.

Liu, Yanlan; Ai, Kelong; Liu, Jianhua; Yuan, Qinghai; He, Yangyang; Lu, Lehui · Adv Healthc Mater · 2012

basic_science · Level V

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Abstract

A novel CT contrast agent denoted as BaYbF(5) @SiO(2) @PEG is presented. The as-prepared nanoparticles exhibit significantly enhanced contrast efficacy relative to clinical iodinated agents and maintain higher X-ray attenuation at different voltages, suitable for diagnostic imaging of various patients. Prolonged circulation time in vivo and low toxicity mean the nanoparticles perform excellently in in-vivo X-ray CT angiography.

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