Anti-cAngptl4 Ab-conjugated N-TiO(2) /NaYF(4) :Yb,Tm nanocomposite for near infrared-triggered drug release and enhanced targeted cancer cell ablation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184779.
- Also identified by DOI 10.1002/adhm.201200055.
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Abstract
Nanomedicine: NIR-active N-TiO(2) /NaYF(4) :Yb,Tm nanocomposites (NCs) were synthesized for the first time and its potential applications in drug release and targeted cancer cell ablation are explored. Upon 980 nm laser irradiation, the anti-cAngptl4 Ab-conjugated N-TiO(2) /NaYF(4) :Yb,Tm NCs shows a significant increase in apoptotic A-5RT3 cells when compared with that of the unconjugated NCs. The mechanisms for NIR-induced photocatalysis, drug release and targeted cancer cell killing are proposed.
Medical subject headings
- Antibodies, Monoclonal
- Fluorides
- Hyperthermia, Induced
- Nanocapsules
- Neoplasms, Experimental
- Titanium
- Yttrium