Latent TGF-β hydrogels for cartilage tissue engineering.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184781.
- Also identified by DOI 10.1002/adhm.201200038.
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Abstract
A biomimetic delivery strategy for transforming growth factor beta (TGF-β) is described, in which TGF-β is presented in a latent form (the small latent complex, SLC), which is inactive until modified by the actions of the cells. In this work, SLC is tethered to a hyaluronic acid hydrogel scaffold to enhance in vitro chondrogenesis.
Medical subject headings
- Cartilage
- Chondrocytes
- Tissue Engineering
- Tissue Scaffolds
- Transforming Growth Factor beta