Novel biopolymers to enhance endothelialisation of intra-vascular devices.

Pernagallo, Salvatore; Tura, Olga; Wu, Mei; Samuel, Kay; Diaz-Mochon, Juan J; Hansen, Anna; Zhang, Rong; Jackson, Melany et al. · Adv Healthc Mater · 2012

other · Level V

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Abstract

Rapid endothelisation is of critical importance in the prevention of adverse remodelling after device implantation. Currently, there is a need for alternative strategies to promote re-endothelialisation for intravascular stents and vascular grafts. Using polymer microarray technology 345 polymers are comprehensively assessed and a matrix is identified that specifically supports both progenitor and mature endothelial cell activity in vitro and in vivo while minimising platelet attachment.

Medical subject headings