Antibody-targeted drug delivery to injured arteries using layered double hydroxide nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184804.
- Also identified by DOI 10.1002/adhm.201200069.
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Abstract
Targeted local delivery of a nanoparticle-based, antibody-targeted, and low molecular weight heparin (LMWH) delivery system successfully reduces restenosis and thrombus formation in an animal model. An antibody recognizing cross-linked fibrin (XLF) D-dimer is successfully conjugated to layered double hydroxide nanoparticles. Use of the anti-XLF-conjugated LMWH-carrying layered double hydroxide nanoparticles shows successful targeting of the nanoparticles (red) to the injured artery wall (green), resulting in decreased neointimal thickening and thrombus formation.
Medical subject headings
- Antibodies, Monoclonal
- Carotid Artery Injuries
- Hydroxides
- Nanocapsules