Hierarchical fibrillar scaffolds obtained by non-conventional layer-by-layer electrostatic self-assembly.

Oliveira, Sara M; Silva, Tiago H; Reis, Rui L; Mano, João F · Adv Healthc Mater · 2013

basic_science · Level V

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Abstract

A new application of layer-by-layer assembly is presented, able to create nano/micro fibrils or nanocoatings inside 3D scaffolds using non-fibrillar polyelectrolytes for tissue-engineering applications. This approach shows promise for developing advanced scaffolds with controlled nano/micro environments, and nature and architectures similar to the natural extracellular matrix, leading to improved biological performance.

Medical subject headings