Mimicking the biological ligand-receptor principle for universal target gene delivery mediated by avidin-biotin interaction.

Qu, Wei; Ren, Shan; Kuang, Ying; Jiang, Xue-Jun; Zhuo, Ren-Xi; Zhang, Xian-Zheng · Adv Healthc Mater · 2013

basic_science · Level V

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Abstract

A facile and flexible targeting gene-delivery strategy is reported by mimicking the biological ligand-receptor principle based on avidin-biotin interaction. In vitro and in vivo investigations demonstrate that this strategy provides a simple, but universal alternative for potential target gene delivery as well as drug delivery.

Medical subject headings