Protein-engineered injectable hydrogel to improve retention of transplanted adipose-derived stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23184882.
- Also identified by DOI 10.1002/adhm.201200293 and PMC identifier 3926432.
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Abstract
Improved retention of transplanted stem cells is achieved through minimally invasive delivery in MITCH, a mixing-induced two-component hydrogel that was engineered to possess shear-thinning and self-healing thixotropic properties. MITCH, an ideal injectable cell-delivery vehicle, supports 3D stem-cell culture, resulting in high cell viability and physiologically relevant cell morphology.
Medical subject headings
- Adipose Tissue
- Biopolymers
- Hydrogel, Polyethylene Glycol Dimethacrylate
- Protein Engineering
- Recombinant Proteins
- Stem Cell Transplantation
- Stem Cells
- Tissue Scaffolds