Nanostructure-mediated transport of biologics across epithelial tissue: enhancing permeability via nanotopography.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23186530.
- Also identified by DOI 10.1021/nl3037799 and PMC identifier 4418930.
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Abstract
Herein, we demonstrate that nanotopographical cues can be utilized to enable biologics >66 kDa to be transported across epithelial monolayers. When placed in contact with epithelial monolayers, nanostructured thin films loosen the epithelial barrier and allow for significantly increased transport of FITC-albumin, FITC-IgG, and a model therapeutic, etanercept. Our work highlights the potential to use drug delivery systems which incorporate nanotopography to increase the transport of biologics across epithelial tissue.
Medical subject headings
- Biological Products
- Epithelium
- Nanostructures