The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23187131.
- Also identified by DOI 10.1172/JCI66420 and PMC identifier 3533566.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.
Medical subject headings
- Aneuploidy
- Cell Transformation, Neoplastic
- Centrosome
- Endopeptidases
- Genes, Tumor Suppressor
- Tumor Suppressor Proteins