Mitochondrial heme: an exit strategy at last.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23187133.
- Also identified by DOI 10.1172/JCI66607 and PMC identifier 3533263.
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Abstract
The transport of heme across membranes is critical for iron absorption, the formation of hemoglobin and other hemoproteins, and iron recycling in macrophages. However, the identity of heme transport proteins has been elusive. In this issue of the JCI, Chiabrando et al. reveal that an isoform of the feline leukemia virus subgroup C receptor (FLVCR1) exports heme from the mitochondria and is critical for erythroid differentiation.
Medical subject headings
- Cell Differentiation
- Erythrocytes
- Membrane Transport Proteins
- Mitochondrial Proteins
- Receptors, Virus