Are epsins a therapeutic target for tumor angiogenesis?
Level V
Where this comes from
- Record sourced from PubMed, PMID 23187137.
- Also identified by DOI 10.1172/JCI66171 and PMC identifier 3533565.
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Abstract
Solid tumor growth requires the formation of new blood vessels to supply nutrients and oxygen to the malignant cells; one approach to cancer therapy is to block this process by inhibiting VEGF signaling. In this issue of the JCI, Pasula et al. demonstrate a surprising role of epsins--proteins involved in endocytosis--in tumor angiogenesis via their modulation of VEGF signaling. Their findings suggest that these proteins might represent a new target for the development of cancer therapeutics.
Medical subject headings
- Adaptor Proteins, Vesicular Transport
- Cell Proliferation
- Human Umbilical Vein Endothelial Cells
- Signal Transduction
- Vascular Endothelial Growth Factor A