Switching photonic and electrochemical functions of a DNAzyme by DNA machines.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23194295.
- Also identified by DOI 10.1021/nl303894h.
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Abstract
DNA nanostructures acting as DNA machines are described. Specifically, DNA "walkers" assembled on nucleic acid scaffolds and triggered by fuel/antifuel strands are activated in solution or on surfaces, for example, electrodes or semiconductor CdSe/ZnS quantum dots (QDs). The DNA machines led to the switchable formation or dissociation of the hemin/G-quadruplex DNAzyme on the DNA scaffolds. This enabled the chemiluminescence, chemiluminescence resonance energy transfer (CRET), electrochemical, or photoelectrochemical transduction of the switchable states of the different DNA machines.
Medical subject headings
- DNA
- DNA, Catalytic
- Electrochemical Techniques