Microfluidic assisted self-assembly of chitosan based nanoparticles as drug delivery agents.

Majedi, Fatemeh Sadat; Hasani-Sadrabadi, Mohammad Mahdi; Emami, Shahriar Hojjati; Shokrgozar, Mohammad Ali; VanDersarl, Jules John; Dashtimoghadam, Erfan; Bertsch, Arnaud; Renaud, Philippe · Lab Chip · 2013

basic_science · Level V

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Abstract

We present a microfluidic platform for the synthesis of monodisperse chitosan based nanoparticles via self-assembly at physiological pH. The resultant nanoparticles are shown to encapsulate hydrophobic anticancer drugs while providing a sustainable release profile with high tunability.

Medical subject headings