Adverse reactions to metal-on-metal implants.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23208186.
- Also identified by DOI 10.1038/nrrheum.2012.218.
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Abstract
New data demonstrate that cobalt ions promote immune system activation through Toll-like receptor 4 signalling. This finding adds to our understanding of the adverse innate and adaptive immune reactions evoked by debris released from metal-on-metal total or resurfacing joint replacement implants, which have provoked recommendations against their use.
Medical subject headings
- Alkaline Phosphatase
- Cobalt
- Hip Prosthesis
- Toll-Like Receptor 4