Core-shell hydrogel microcapsules for improved islets encapsulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23208618.
- Also identified by DOI 10.1002/adhm.201200341 and PMC identifier 3814167.
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Abstract
Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.
Medical subject headings
- Alginates
- Capsules
- Diabetes Mellitus, Experimental
- Hydrogels
- Islets of Langerhans Transplantation
- Tissue Scaffolds