Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region.
basic_science · Level V
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- Record sourced from PubMed, PMID 23212382.
- Also identified by DOI 10.1038/ncomms2261 and PMC identifier 4931925.
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Abstract
Different places may share common features, but are coded by distinct populations of CA3 neurons in the hippocampus. Here we show that chemical or genetic suppression of adult neurogenesis in the hippocampus impairs this population-based coding of similar (but not dissimilar) contexts. These data provide a neural basis for impaired spatial discrimination following ablation of adult neurogenesis, and support the proposal that adult neurogenesis regulates the efficiency of a pattern separation process in the hippocampus.
Medical subject headings
- CA3 Region, Hippocampal
- Neurogenesis