Linking glycogen and senescence in cancer cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 23217251.
- Also identified by DOI 10.1016/j.cmet.2012.11.010.
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Abstract
Glycogen metabolism operates as an alternative energy source, enabling cell growth under conditions of metabolic stress. Favaro et al. (2012) now demonstrate that in hypoxic cancer cells, depletion of liver glycogen phosphorylase causes glycogen accumulation, leading to oxidative stress, induction of senescence, and impaired tumor growth in vivo.