Is hyperinsulinemia required to develop overeating-induced obesity?
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- Record sourced from PubMed, PMID 23217253.
- Also identified by DOI 10.1016/j.cmet.2012.11.009 and PMC identifier 3740751.
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Abstract
Type 2 diabetes is characterized by insulin resistance, and the hyperinsulinemia commonly observed in patients is thought to be a compensatory response. Yet it has been difficult to disentangle cause and effect. Mehran et al. (2012) provide genetic evidence that a reduction of insulin secretion prevents high-fat feeding-induced obesity.