UPS delivers pluripotency.

Okita, Yasutaka; Nakayama, Keiichi I · Cell Stem Cell · 2012

editorial · Level V

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Abstract

In this issue of Cell Stem Cell, Buckley et al. (2012) show that the ubiquitin-proteasome system (UPS) regulates pluripotency in embryonic stem cells and induced pluripotent stem cells, opening the door to a better understanding at the system level of protein dynamics responsible for the maintenance and induction of pluripotency.