MSCs, macrophages, and cancer: a dangerous ménage-à-trois.
editorial · Level V
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- Record sourced from PubMed, PMID 23217416.
- Also identified by DOI 10.1016/j.stem.2012.11.016.
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Abstract
Two studies in this issue of Cell Stem Cell highlight context-dependent roles for MSCs in controlling tumor growth. Lee et al. (2012) show that preactivated MSCs have antitumor effects upon adoptive transfer in vivo, and Ren et al. (2012) show that tumor-resident MSCs can promote tumor growth by influencing macrophages.