Utf1: Goldilocks for ESC bivalency.
basic_science · Level V
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- Record sourced from PubMed, PMID 23217417.
- Also identified by DOI 10.1016/j.stem.2012.11.012 and PMC identifier 3684620.
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Abstract
Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.