Small RNAs of opposite sign… but same absolute value.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23217700.
- Also identified by DOI 10.1016/j.cell.2012.11.032.
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Abstract
In ciliates, small RNAs have been shown to target foreign sequences for silencing via elimination from the somatic genome. Fang et al. now reveal a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax that likewise enable genomic self versus nonself discrimination, this time by specifying self sequences for genome retention.