Cleaning up: ER-associated degradation to the rescue.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23217703.
- Also identified by DOI 10.1016/j.cell.2012.11.012 and PMC identifier 3521611.
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Abstract
All cellular proteins are subject to quality control "decisions," which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated degradation (ERAD).
Medical subject headings
- Endoplasmic Reticulum
- Endoplasmic Reticulum-Associated Degradation
- Proteins
- Secretory Pathway