Shedding light on apoptosis at subcellular membranes.

Kale, Justin; Liu, Qian; Leber, Brian; Andrews, David W · Cell · 2012

basic_science · Level V

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Abstract

Regulation of apoptosis by Bcl-2 family proteins is a paradigm for complex protein-protein and protein-membrane systems. Elucidating the molecular mechanisms of these interactions in vitro in live cells and in animal studies has been significantly enhanced by using fluorescence techniques.

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