Opioid therapies and cytochrome p450 interactions.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23218233.
- Also identified by DOI 10.1016/j.jpainsymman.2012.08.013.
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Abstract
Adverse drug reactions are common and associated with substantial economic and human costs. Particularly among older adult populations, preventable adverse drug reactions are often caused by drug-drug interactions. All analgesics have side effect profiles and many have known drug-drug interactions. Opioids are recognized as a necessary option for managing moderate-to-severe pain, yet many opioid side effects can be enhanced by metabolic interactions within the liver, involving other drugs, diseases, or genetics.
Medical subject headings
- Analgesics, Opioid
- Cytochrome P-450 Enzyme System
- Liver
- Opioid-Related Disorders
- Pain