Metabolic jet lag when the fat clock is out of sync.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23223058.
- Also identified by DOI 10.1038/nm.3010 and PMC identifier 3731391.
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Abstract
There is a growing appreciation of the importance of circadian regulation in energy homeostasis, and the dysregulation of the circadian clock has been associated with obesity and metabolic abnormalities. A new study shows that adipocyte-specific deletion of a core circadian clock gene, <i>Bmal1</i>, in mice shifts the timing of their feeding behavior, resulting in obesity (aaa-bbb).
Medical subject headings
- ARNTL Transcription Factors
- Adipocytes
- Appetite Regulation
- Circadian Rhythm
- Energy Metabolism
- Obesity