Measuring behavior of animal models: faults and remedies.
basic_science · Level V
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- Record sourced from PubMed, PMID 23223171.
- Also identified by DOI 10.1038/nmeth.2252.
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Abstract
Widely used behavioral assays need re-evaluation and validation against their intended use. We focus here on measures of chronic anxiety in mouse models and posit that widely used assays such as the open-field test are performed at the wrong time, for inadequate durations and using inappropriate mouse strains. We propose that behavioral assays be screened for usefulness on the basis of their replicability across laboratories.
Medical subject headings
- Anxiety
- Behavior, Animal
- Exploratory Behavior
- Models, Animal
- Psychological Tests