Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23223959.
- Also identified by DOI 10.1039/c2lc41144j.
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Abstract
Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results.
Medical subject headings
- Biosensing Techniques
- Gold
- Metal Nanoparticles