Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease.

Li, Xuejin; Vlahovska, Petia M; Karniadakis, George Em · Soft Matter · 2013

review · Level V

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Abstract

We review recent advances in multiscale modeling of the mechanics of healthy and diseased red blood cells (RBCs), and blood flow in the microcirculation. We cover the traditional continuum-based methods but also particle-based methods used to model both the RBCs and the blood plasma. We highlight examples of successful simulations of blood flow including malaria and sickle cell anemia.