Pluripotent stem cells: immune to the immune system?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23241742.
- Also identified by DOI 10.1126/scitranslmed.3005090 and PMC identifier 3638038.
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Abstract
Human embryonic stem cells (hESCs), initially thought to be immune privileged cells, are now known to be susceptible to immune recognition. Human induced pluripotent stem cells (iPSCs) have been proposed as a potential source of autologous stem cells for therapy, but even these autologous stem cells may be targets of immune rejection. With clinical trials on the horizon, it is imperative that the immunogenicity of hESCs and iPSCs be definitively understood.
Medical subject headings
- Immune System
- Immunity
- Pluripotent Stem Cells