Breast cancer stem cells: we've got them surrounded.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23251003.
- Also identified by DOI 10.1158/1078-0432.CCR-12-3450 and PMC identifier 6276109.
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Abstract
Breast cancer stem cells are regulated by cell intrinsic pathways as well as by elements in the tumor microenvironment. New evidence suggests that an important interaction between the interleukin (IL)-8 receptor CXCR1/2 and HER2 is involved in this regulation. Simultaneous targeting of these pathways provides a novel therapeutic approach.
Medical subject headings
- Breast Neoplasms
- Neoplastic Stem Cells
- Erb-b2 Receptor Tyrosine Kinases
- Receptors, Interleukin-8A
- Receptors, Interleukin-8B