TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 23251635.
- Also identified by DOI 10.1371/journal.pone.0051825 and PMC identifier PMC2825243.
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Abstract
Overexpression of the cation-permeable channel TRPM8 in prostate cancers might represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of prostate cancer cells. We have used two recently described and highly specific blockers, AMTB and JNJ41876666, and RNAi to determine the relevance of TRPM8 expression in the proliferation of non-tumor and tumor cells. Inhibition of the expression or function of the channel reduces proliferation rates and proliferative fraction in all tumor cells tested, but not of non-tumor prostate cells. We observed no consistent acceleration of growth after stimulation of the channel with menthol or icilin, indicating that basal TRPM8 expression is enough to sustain growth of prostate cancer cells.