How does doxorubicin work?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23256047.
- Also identified by DOI 10.7554/eLife.00387 and PMC identifier 3524826.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A new mechanism involving cleavage of a transcription factor called CREB3L1 has been proposed to explain the anti-tumour effects of doxorubicin.
Medical subject headings
- Antibiotics, Antineoplastic
- Biomarkers, Tumor
- Cyclic AMP Response Element-Binding Protein
- Doxorubicin
- Gene Expression Regulation, Neoplastic
- Nerve Tissue Proteins