Loaded dice for human genome mutation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23260131.
- Also identified by DOI 10.1016/j.cell.2012.12.002.
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Abstract
Not all bases in the human genome are equally prone to chance mutations. Michaelson et al. show that individuals can acquire clusters of de novo DNA changes and propose that the likelihood of single base pair change differs across three orders of magnitude.