Blending hippo and WNT: sharing messengers and regulation.
review · Level V
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- Record sourced from PubMed, PMID 23260132.
- Also identified by DOI 10.1016/j.cell.2012.12.007.
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Abstract
Two new studies reveal ways in which the Wnt pathway commandeers Hippo components for signaling. Azzolin et al. show how the Hippo transcription factor TAZ mediates Wnt signals, and Rosenbluh et al. show how β-catenin and YAP1 form a kinase-regulated complex with transcription factor TBX5.