A dimer to bridge early autophagosomal membranes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23260133.
- Also identified by DOI 10.1016/j.cell.2012.12.008.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The Atg1/ULK complex plays a key role in the early stages of autophagosome assembly. In this issue, Ragusa et al. reveal the molecular basis for some interactions within this complex, finding that the crescent-shaped Atg17 dimer is critical for autophagy, whereas Atg1 may have the ability to cluster membranes.