Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling.
basic_science · Level V
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- Record sourced from PubMed, PMID 23269831.
- Also identified by DOI 10.1073/pnas.1214718110 and PMC identifier 3545745.
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Abstract
Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1 (NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity, but it is unclear whether NL1 controls synaptic accumulation or function of the receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs at postsynaptic sites. This function relies on extracellular, NL1 isoform-specific sequences that facilitate biochemical interactions between NL1 and the NMDAR GluN1 subunit. Our work uncovers NL1 isoform-specific cis-interactions with ionotropic glutamate receptors as a key mechanism for controlling synaptic properties.
Medical subject headings
- Cell Adhesion Molecules, Neuronal
- Neuronal Plasticity
- Receptors, Ionotropic Glutamate
- Receptors, N-Methyl-D-Aspartate
- Synapses
- Synaptic Transmission